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5. Features of cytogenetic damage in the buccal epithelium of women with congenital developmental anomalies of the fetus, living in conditions radiation, chemical and combined environmental pollution

Features of cytogenetic damage in the buccal epithelium of women with congenital developmental anomalies of the fetus, living in conditions radiation, chemical and combined environmental pollution

Korsakov A.V. (1), Troshin V.P. (2)

1) Bryansk State Technical University, Bryansk, Russian Federation; 2) Bryansk city hospital №1, Bryansk, Russian Federation

Korsakov A.V.: e-mail: korsakov_anton@mail.ru; Troshin V.P.: e-mail: vptbr32@yandex.ru.

Abstract

Comparative evaluation of changes, indicators of proliferation and degradation of the nucleus in buccal epithelium in 178 puerperas 20-30 years with congenital malformations and without congenital malformations of the fetus, living in areas with different levels of radiation after the Chernobyl disaster) combined chemical and radiation-chemical pollution. It is estimated that women with congenital malformations of the fetus, living in conditions of combined radiation and chemical pollution the total frequency of cells with the destruction of the nucleus (karyopyknosis, karyorhexis and karyolysis) reaches the highest values, which may indicate a synergistic action of radiation and chemical factors on the frequency of cytological abnormalities. It was determined that the puerperium congenital malformations of the fetus, living in ecologically unfavorable areas, the frequency of cells with karyopyknosis 1,5 and karyolysis 2,0 (p<0.05) times higher than mothers without congenital malformations of the fetus. The obtained results can be recommended as one of the criteria of identifying groups at higher risk of formation of congenital malformations in the fetus when an individual survey of women planning pregnancy.

Keywords

congenital developmental anomalies of the fetus, woman in childbirth, cytogenetic violations, buccal epithelium, micronuclear test, ecological trouble, Bryansk region

Цит.: Korsakov A.V., Troshin V.P. Features of cytogenetic damage in the buccal epithelium of women with congenital developmental anomalies of the fetus, living in conditions radiation, chemical and combined environmental pollution // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2016; 1/2016; с. 93-101