Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
1) Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, St. Petersburg, 199034, Russia; 2) Saint Petersburg Institute of Bioregulation and Gerontology, Ave. Dynamo, St. Petersburg, 197110, Russia
Kuznetsova Tamara G., D.Sci. of Biology, MD; ORCID ID: 0000-0002-0196-0519; dr.tamara.kuznetspva@gmail.com; Golubeva Inna Y., PhD; ORCID ID: 0000-0003-3698-9036; antropoid-kiu@yandex.ru; Trofimova Svetlana V., MD, professor; ORCID ID: 0000-0002-5190-1824; dr.s.trofimova@gmail.com; Khavinson V., MD, professor; ORCID ID: 0000-0001-5798-255X; vladimir@khavinson.ru; Shuvaev Vyacheslav T., D.Sci. of Biology, MD, ORCID ID: 0000-0002-7073-8073
Age-related changes in human cognitive activity require an appropriate medicated correction. The St. Petersburg Institute of Bioregulation and Gerontology studies the effect of peptides on aging processes. Taking into account the high similarity of the psychophysiological processes of monkeys and humans we studied the influence of Pinealon on the cognitive activity of macaques. Material and methods. The work was carried out on two healthy rhesus macaques (13 ± 0.9 years) in two stages using a modified visual stimuli distinction method [Bongard, 1967] that was adapted for cognitive studies in primates. Prior to the beginning of the study, an instrumental conditioned reflex was formed in macaques – pressing a neutral image of a visual stimulus on the touch screen of a monitor. Then they were given the task of distinguishing an informational sign in stimuli with one element in the stimulus before they reached 75% level of success. Then a control study was conducted, including 4 elements in stimuli with the same informational signs. Before the second stage, the 10-day course of peptide Pinealon per os was held and the experiment was repeated with a set of new incentives. We compared the speed, success of training and the ability to concentrate before and after the use of peptide Peinealon. Results. After the use of Peinealon macaques had: a significant (p<0.01) reduction in the duration of training; a significant (p<0.001) reduction in the time of motor reactions when choosing stimuli. Also, a direct correlation was found between the increasing number of concentration reactions prior to the choice making and the success of the task. Conclusion. Rhesus monkeys are able to form a generalized image of an informative trait and transfer the experience gained to new situations; Pinealon improved spatial orientation in the implementation of the selection of visual stimuli; the use of the peptide led to a reduction in the motor response time due to an increase in the level of energy supply of the muscle tissue; Pinealon ked to the improvement of selective attention by reducing the overall excitability of macaques and enhancing the connections between the frontal-temporal-parietal structures of the monkey brain responsible for the cognitive properties of the subject.
Macaca mulatta; peptide Pinealon; earning success; attention; cognitive abilities; aging
DOI: 10.32521/2074-8132.2019.1.062-073
Цит.: Kuznetsova T.G., Golubeva I.Yu., Trofimova S.V., Khavinson V.Kh., Shuvaev V.T. The influence of the Pinealon tripeptide on the rehabilitation of cognitive functions in the aging process using the example of rhesus monkeys (Macaca mulatta) // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2019; 1/2019; с. 62-73
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