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5. Association of three gene polymorphisms (TGF B1, IGF I and IGF II) with a case rate an idiopathic scoliosis, and also with body constitution and rates of skeletal maturation

Association of three gene polymorphisms (TGF B1, IGF I and IGF II) with a case rate an idiopathic scoliosis, and also with body constitution and rates of skeletal maturation

Spitsyn V.A. (1), Raygorodskaya M.P. (2), Ryzhkov I.I. (3), Chtetsov V.P. (2), Negasheva M.A. (2)

1) Federal state budgetary institution «Research Centre for medical genetics» of Russian Acad-emy of Medical Sciences, Moscow; 2) Lomonosov Moscow State University, Faculty of biology, Department of anthropology, Leninskie Gory, 1, p.12, Moscow, 119991, Russia

Spitsyn Viktor A.; Raygorodskaya M.P., e-mail: ramashka90@mail.ru; Ryzhkov I.I., e-mail: ecolab@med-gen.ru; Chtetsov V.P.; Negasheva Marina A., Ph.D., D.Sc., ORCID ID: 0000-0002-7572-4316, e-mail: negasheva@mail.ru

Abstract

Polymorphisms on three genetic systems: transforming growth factor beta-1 (TGFb1), insulin-like growth factor I (IGF I) and insulin-like growth factor II (IGFII) at 600 children and adolescents (is conditional healthy – 300 patients with idiopathic scoliosis) were investigated. Reliable differences were observed between all scoliosis patients totality and corresponding control group as compared with geno-types and alleles distributions of TGFb1 (c2 = 19.99 and c2 = 16.04 accordingly). Sexual differences in genotypes distributions of IGFII +3123 locus were revealed. By comparison of occurrence genotypes and alleles of IGFII +3123 in cohorts sick the idiopathic scoliosis and is conditional healthy girls had been established connection with high level of reliability where in a subgroup of patients genotype AA meets autentically less often, than among is conditional healthy. We observed associations between habitus of studied boys and IGF II factors. Differences between IGF II genotypes in studied males groups with an asthenic and normosthenic constitution were observed (c2 = 6.81; d.f.=2; P<0.05).

Keywords

growth factor genes, polymorphisms, idiopathic scoliosis, skeletal maturation

Цит.: Spitsyn V.A., Raygorodskaya M.P., Ryzhkov I.I., Chtetsov V.P., Negasheva M.A. Association of three gene polymorphisms (TGF B1, IGF I and IGF II) with a case rate an idiopathic scoliosis, and also with body constitution and rates of skeletal maturation // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2012; 3/2012; с. 121-128