Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
1) Federal state budgetary institution “Research Centre for Medical Genetics”, Moscow; 2) Federal state budgetary institution “Institute of ethnology and anthropology”, Russian Academy of Sciences, Moscow
Bychkovskaya Luybov S.: e-mail: ecogen@medgen.ru; Balinova Natalia V.: e-mail: balinovs@mail.ru; Spitsyna Nailya Kh.: e-mail: nailya.47@mail.ru; Spitsyn Viktor A.
Introduction. The study was aimed at an in-depth analysis of known polymorphisms and at discovering new systems of enzyme and other proteins in human milk. The second task was establishing their connections with morphofunctional features of newborns and physiological characteristics of parturients. Materials and methods. Methods for the identification of polymorphic systems of enzyme and other proteins in human breast milk have been developed and implemented. Phenotypes of phosphoglucomutase 4 (PGM4), lacto esterase (E3), б-amylase 1 (Amy1) and lactoferrin 1 (LF1) were identified in 180 milk samples taken from Moscow women of East Slavic origin. Three out of four polymorphic systems have been identified for the first time. Results. The results of the study of the isoenzyme spectrum of phosphoglucomutase in human milk revealed 6 discrete electrophoretic forms of PGM 4 controlled by 4 alleles. For the first time, the spectrum of the cholinesterase enzyme of human milk – lacto esterase locus 3 (E3) and spectrum of б-amylase in human milk was obtained by electrophoresis. Of greatest interest is the analysis of the relationship of polymorphisms of lacto esterase (E3), phosphoglucomutase (PGM 4), lactoferrin (LF) and amylase (AMY 1) with the somatotype of newborns. Reliable correlations between anthropometric characteristics of newborns and polymorphism in PGM4 and LF systems were established. Newborn weight increase or decrease trends were revealed that are associated with a certain types of genetic systems. The results of examining the correlation of the discrete genetic polymorphism of the AMY 1, E3, PGM4 and LF systems with female reproductive function revealed a connection with obstetric pathologies such as miscarriages, spontaneous abortions and stillbirths. It was shown for the first time that the genetic polymorphism of amylase in human milk is reliably associated with the level of lactation of parturients.
human breast milk, genetic polymorphism, somatotype of newborns, reproductive function
DOI: 10.32521/2074-8132.2018.1.043-049
Цит.: Bychkovskaya L.S., Balinova N.V., Spitsyna N.Kh., Spitsyn V.A. Polymorphism of genes expressed in breast milk in connection with the somatotype of the newborn and reproductive function of women // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2018; 1/2018; с. 43-49
Download text