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5. Polarization of frequencies alleles of different genes is the widespread phenomenon in contrast groups of humans

Polarization of frequencies alleles of different genes is the widespread phenomenon in contrast groups of humans

Spitsyn V.A.

Federal State Budgetary Institution «Research Centre for Medical Genetics», RAMS, Moscow

Spitsyn Viktor A.

Abstract

In 1986–2010 genetic polymorphisms have been studied in cohorts of patients with multifactorial illnesses, and also in groups of persons steady against the development of considered diseases. The effect of polarization of allelic frequencies, namely the phenomenon opposite to directional changes of their concentration from the control populations in many of the studied independent genes has been established in the groups of patients in comparison to cohorts of persons considered steady against their development. The effect of allelic frequencies polarization was observed also concerning the degree of efficiency of treatment of some widespread diseases, including some occupational pathologies. The phenomenon opposite to directional changes in allelic frequencies has been noted for groups of patients, suffering from occupational illnesses when compared with the healthyl workers with high record of service. The polar divergence of allelic frequencies in a complex of genes from the control is shown also for modern human populations with different degree of adaptation to natural factors of environment at the level of individual and group distinctions in their health status. The contrast-grouping principle of comparison of genetic structure in different groups of individuals allows identifying the effect of allelic frequencies polarization in separate genes and their complex. Polar fluctuations of allelic frequencies reflect their physiological distinctions in each locus in determination of corresponding protein products.

Keywords

frequencies alleles polarization, natural populations, widespread diseases, occupational pathology

Цит.: Spitsyn V.A. Polarization of frequencies alleles of different genes is the widespread phenomenon in contrast groups of humans // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2012; 1/2012; с. 4-16