1. Home
2. Archive
3. 2013
4. 1/2013
5. Association of the polymorphic gene systems FTO and GHRL with risk of obesity development in children and adolescents

Association of the polymorphic gene systems FTO and GHRL with risk of obesity development in children and adolescents

Bondareva E.A., Godina E.Z.

Lomonosov Moscow State University, Anuchin Research Institute and Museum of Anthropology, Mokhovaya st., 11, Moscow, 125009, Russia

Bondareva E.A., Ph.D., ORCID ID: 0000-0003-3321-7575, e-mail: Bondareva.E@gmail.com; Godina E.Z., D.Sc., prof., ORCID ID: 0000-0002-0692-420X, e-mail: egodina11@gmail.com

Abstract

Introduction. The problem of human fatness is one of the most urgent in the modern world. Studies in the field of anthropogenetics and functional genomics revealed some genetic determinants of increased fat accumulation and, as a consequence, of obesity development. Materials and Methods. Samples of buccal smears were collected from 10–17-year-olds, living in Arkhangelsk region for molecular genetic analysis of associations between Т/А (rs9939609) polymorphism of the FTO gene and C/A (rs696217) polymorphism of GHRL gene and the risk of obesity development. The whole sample was divided into three subgroups: those with obesity and low fatness (25 and 36 persons correspondingly, 10#BMI$90 percentile according to local references), and also with normal BMI (30 persons). Results and discussion. Frequencies of the genotype distribution of the FTO and GHRL polymorphisms for the whole sample are as follows: FTO*АА – 20%, FTO*АТ – 49% and FTO*ТТ – 13%. GHRL*AA – 1%, GHRL*AC – 13% and GHRL*CC – 86%. The distribution of the FTO genotypes reveals nonrandom differences (Pearson’s chi-squared test (χ 2) = 11.3 р=.02, df=4). For the GHRL gene no significant differences were found. The presence of rare allele of the FTO gene polymorphic system in the genotypes of investigated Archangelsk children could be considered as a risk-factor of obesity development.

Keywords

anthropology, anthropogenetics, auxology, obesity, FTO polymorphism, GHRL polymorphism, molecular genetic markers

Цит.: Bondareva E.A., Godina E.Z. Association of the polymorphic gene systems FTO and GHRL with risk of obesity development in children and adolescents // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2013; 1/2013; с. 111-119