Moscow University Anthropology Bulletin

Features of the cytogenetic status of women in labor with congenital developmental anomalies of the fruit, living in conditions of chemical pollution of atmospheric air

Korsakov A.V. (1), Yablokov A.V. (2), Troshin V.P. (3), Pygach L.I. (1) , Sidorov I.V. (2), Zhilin A.V. (3), Mikhalev V.P. (4)

1) Bryansk State Technical University, Bryansk; 2) Instituteof biology of development of Koltsov of the Russian Academy; 3) Bryansk pathoanatomical Institute, Bryansk; 4) Bryansk State University n.a. academician I.G. Petrovskiy, Bryansk

Korsakov A.V., e-mail: korsakov_anton@mail.ru; Yablokov A.V., e-mail: alexey.ablokov@gmail.com; Troshin V.P., e-mail: vptbr32@yandex.ru; Pygach L.I., e-mail: lip58@mail.ru; Sidorov I.V., e-mail: patanat32@gmail.com; Zhilin A.V., e-mail: patanat32@gmail.com; Mikhalev V.P., e-mail: korsakov_anton@mail.ru

Abstract

To define possible influence of chemical pollution of atmospheric air on the frequency of cytogenetic violations in a bukkalny epithelium of women in labor with congenital developmental anomalies of a fruit. The comparative assessment of frequency of cytogenetic violations, indicators of proliferation and kernel destruction in a bukkal epithelium of women in labor of 20-30 years with congenital developmental anomalies of a fruit and without the congenital developmental anomalies of a fruit living in territories with various level of chemical pollution of atmospheric air is carried out. Levels of chemical pollution of territories of the Bryansk region fluctuate over a wide range – from 0.5 to 13401.2 tons per year on gross emissions in the atmosphere, from 0.5 to 37161.3 kg/km2 on gross emissions in the atmosphere in terms of the area of the area and from 0 to 171.6 kg/person/year on average annual toxic loads of the inhabitant. Researches of the cytogenetic status of women in labor were conducted on the basis of a method of the analysis of microkernels and anomalies of a kernel in eksfoliativny cells of the person. For half a year (march-august, 2013) at 70 women in labor the fence of a bukkal epithelium was carried out. From each woman in labor it was studied from 500 to 1500 cages, then recalculation on 1000 cages (‰) was made. In total 68 000 cages are analysed. At women in labor both with congenital developmental anomalies of a fruit, and without the congenital developmental anomalies of a fruit living in conditions of chemical pollution of atmospheric air, the raised number of cages with kariopiknozy and kariolizisy is registered that points to possible negative influence of technogenic toksikant on the cytogenetic status of a female organism. Thus women in labor with congenital developmental anomalies of a fruit have a frequency of cages with kariopiknozy and in 1.3 (р>0.05), and with kariolizisy in 2.5 (p<0.001) time exceeds similar indicators of women in labor without congenital developmental anomalies of a fruit. The obtained data can serve one of criteria of identification of groups of the increased risk of formation of congenital developmental anomalies at a fruit at mass population inspections of women in labor.

Keywords

Congenital developmental anomalies of a fruit, woman in labor, cytogenetic status, bukkal epithelium, micronuclear test, chemical pollution of the atmosphere, average annual toxic loadings, Bryansk region

Цит.: Korsakov A.V., Yablokov A.V., Troshin V.P., Pygach L.I. , Sidorov I.V., Zhilin A.V., Mikhalev V.P. Features of the cytogenetic status of women in labor with congenital developmental anomalies of the fruit, living in conditions of chemical pollution of atmospheric air // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2014; 2/2014; с. 122-128

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