Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
1) Lomonosov Moscow State University, Institute and Museum of Anthropology, Moscow; 2) RUDN University, Department of physical education and sport, Moscow
Human growth hormone (GH) influences stature, muscle mass, lipid and carbohydrate metabolism and postnatal growth. The +1169A allele of the T/A single nucleotide polymorphism (SNP; rs2665802), located within intron 4 of the human growth hormone 1 (GH1) gene, has been associated with reduced levels of circulating GH and insulin-like growth factor 1. Whether this intronic SNP is itself the functional polymorphism responsible for exerting a direct effect on GH1 gene expression, however, or whether it is instead in linkage disequilibrium with the functional SNP, has been an open question. The aim of the present paper was to study associations between T/A-polymorphism of the GH1 gene with morphological traits and speed-power capacities in Russian male athletes. 225 highly qualified Russian male athletes aged from 18 to 38 years, took part in the investigation. The program included anthropometric measurements (50), testing of speed-power capacities (bicycle ergometry, dynamometry) and the collection of buccal smears for genetical analysis (GH1, rs2665802). Distribution of the genotype frequencies is consistent with Hardy–Weinberg equilibrium (χ2HW=0,03 P=0,86). Significant differences were not revealed both in morphological traits and speed-power capacities.
anthropology, T/A-polymorphism, GH1, height, morphological traits, speed-power capacities, athletes
Цит.: E.A. Bondareva, E.S. Ketlerova Search for associations between T/A polymorphism of the growth hormone gene and some morphological and functional characteristics in athletes // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2017; 2/2017; с. 61-67
Download text