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5. Prenatal and postnatal growth characteristics of children with Gilbert‘s syndrome

Prenatal and postnatal growth characteristics of children with Gilbert‘s syndrome

Botvin‘ev O.K., Dubrovina G.M., Kolotilina A.I.

I.M. Sechenov First Moscow State Medical University, Russia

Abstract

Gilbert‘s syndrome (GS) is a common genetic disease, related to decrease of uridine diphosphate glucuronosyltransferase 1A1 activity in the liver, which leads to bilirubin and other substances’ metabolism impairment. Aim of this study was: to assess specifics of the prenatal and postnatal growth in children with GS. 175 children with GS were examined at the Сhildren’s Сlinical Сity Speransky Нospital (Moscow). Ages ranged from 3 to 17 years. The children were divided into two groups according to unconjugated bilirubin blood level: the 1st group – more than 25 mcmol/l, and the 2nd group – less than 25 mcmol/l. We have examined body mass and body length of children with GS both at birth and in later years. The control group consists of healthy newborns and children aged from 3 to 17 years without GS and other bilirubin metabolism impairments. The newborns with GS had greater both body length (in a greater extent) and body mass in comparison with the healthy ones regardless of the level of unconjugated bilirubin concentration in later years. Children older than 3 years with GS included in the 1st group had greater body length dimensions than children from the 2nd group and the control. There were fewer children with overweight in the 1st group in comparison with the 2nd group and the control. There were no differences in overweight between the 2nd group and the control. Conclusions: As а result of decreased glucuronosyltransferase activity in the liver, children with GS develop metabolic disorders starting from the prenatal period of ontogenesis, which lead to child’s growth stimulation.

Keywords

Gilbert‘s syndrome, children, body mass, body length

Цит.: Botvin‘ev O.K., Dubrovina G.M., Kolotilina A.I. Prenatal and postnatal growth characteristics of children with Gilbert‘s syndrome // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2017; 1/2017; с. 74-79