Вестник Московского университета
Серия XXIII
Антропология
Серия XXIII
Антропология
Department of Anthropology and School of Public Health, Ohio State University, Columbus, USA
Crews Douglas E., e-mail: crews.8@osu.edu.
Over a life span, both failed and successful responses to stressors promote physiological dysfunction, leading eventually to an allostatic load (AL). Adaptive and maladaptive stress responses depend on biology, culture, environment, and previous experience. Additionally, age, sex, occupation, sociocultural factors and self-perceptions affect physiological responses and structure predispositions to non-communicable diseases and mortality. Measurement of AL assesses physiological dysfunction secondary to lifelong responses to stressors. As yet, how genes modulate AL has not been examined. We examined associations of AL with apolipoprotein (Apo) E and H, ACE, and ANP genotypes in 284 American Samoans. AL was measured using seven secondary mediators of allostasis, along with aspects of body habitus and glucose metabolism. AL differed little by Apo H or ANP genotypes. However, significant differences in Al were observed across Apo E and ACE genotypes. Participants with the Apo E 3*2 genotype showed the lowest AL compared to 3*3 or 2*2 genotypes. Women showed the highest AL across all genotypes. Across ACE genotypes, AL was lower in those heterozygous (I/D), than those with the homozygous I/I genotype. Samoan women showed higher AL than men, along with stronger associations of AL with both Apo E genotypes. AL associates significantly with morbidity and mortality across multiple samples, our results suggest these relationships may depend in part on underlying genotypes.
American Samoans, life span, stress, stressors, physiological dysfunction
Цит.: Crews Douglas E., Donley Gwendolyn APOLIPOPROTEIN E AND ACE GENOTYPES MODULATE ALLOSTATIC LOAD // Вестник Московского университета. Серия XXIII. Антропология, 2014; 3/2014; с. 117-117
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