Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
1) Lomonosov Moscow State University, Anuchin Research Institute and Museum of Anthropology, Mokhovaya st., 11, Moscow, 125009, Russia; 2) Vavilov Institute of General Genetics, Russian Academy of Science, Moscow, 119991 Russia
Kozlov Andrew I., PhD, D.Sci.; ORCID ID: 0000-0002-6710-4862; dr.kozlov@gmail.com; Vershubskaya Galina; ORCID ID: 0000-0003-2452-1532; ggver@ya.ru; Borinskaya Svetlana, PhD, D.Sci.; ORCID ID: 0000-0002-9204-2341; borinskaya@vigg.ru.
The aim of the study was to assess the polymorphism of adaptive genes in anthropologically related populations of Komi-Permyaks and Komi-Izhems, who have mastered different variants of management of natural resources. Materials and methods. DNA analysis was conducted on samples from 127 ethnic Komi-Permyaks and 134 Komi Izhems. We genotyped polymorphic loci of APOE, LCT, UCP1, and VDR genes. The information on traditional food composition was obtained from ethnographic literature. Results. The frequencies of the following genotypes and alleles turned out to be different (p < 0.05) in the Komi-Izhem and Komi-Permyak study groups: APOE*е4 0.217 vs 0.144; CC*LCT 0.636 vs 0.470; VDR T*Fok1 0.528 vs 0.400; CT*Fok1 0.288 vs 0.549. The difference between group in A*UCP1-3826 allele frequencies (0.812 vs 0.730) was found insignificant. Discussion. The genetic features and the variants of husbandry correspond to the ecological environment of the groups and provide an adaptive effect both by itself and in combination. The higher prevalence of APOE*е4 among Komi-Izhem reindeer herders is in agree with their protein-lipid based traditional diet: the “thrifty” apolipoprotein е4 slows the absorbing of cholesterol and thus promotes a better digestion of lipids. We regard the higher prevalence of T*LCT, T*Fok1 alleles, and CT*Fok1 VDR genotype in the Komi-Permyaks as an adaptive response to the unfavorable to bone homeorhesis environmental conditions of northern forest. The diet of the Komi-Izhems provided more vitamin D. A weak selection in favor of these alleles and genotype led to a decrease in the number of their carriers among the Komi-Izhems compared to that in the Komi-Permyaks. Conclusion. The adoption of different variants of natural economies has affected the gene pools of the anthropologically proximal populations.
Komi-Permyaks; Komi-Izhems; diet; metabolism; lactase; APOE; thermogenin; UCP; vitamin D; VDR
DOI: 10.32521/2074-8132.2020.4.099-110
Цит.: Kozlov A.I., Vershubskaya G.G., Borinskaya S.A. The divergence of genetic complexes in anthropologically related populations with different types of management of natural resources // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2020; 4/2020; с. 99-110
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