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5. Association of 3826A >G UCP1 gene polymorphism and physical activity level with central obesity

Association of 3826A >G UCP1 gene polymorphism and physical activity level with central obesity

Parfenteva O.I.

Lomonosov Moscow State University, Anuchin Research Institute and Museum of Anthropology, Mokhovaya st., 11, Moscow, 125009, Russia

Parfenteva Olga Ivanovna; ORCID: 0000-0001-7895-6887; parfenteva.olga@gmail.com.

Abstract

Introduction. Identification of genotype-environment interactions has implementation for understanding the etiology of obesity. Here, the association between -3826A>G polymorphism UCP1 (rs1800592) and level of physical activity with obesity-related traits was examined in the group of Russian females. Materials and methods. A cross-sectional study of 124 females of 18-33 years old living in Moscow was performed. The genotype of rs1800592 (UCP1 gene) was determined. Height, body mass, waist, and hip circumferences and body fat mass were measured. Waist to hip ratio (WHR), waist to height ratio (WHtR), body mass index (BMI), and body adiposity index (BAI) were calculated. Quantile regression analysis was used. Results. Quantile regression analysis revealed that the -3826A>G polymorphism of UCP1 (rs1800592) and physical activity were significantly associated with obesity-related traits. However, physical activity had a greater influence on obesity-related traits. Decreased level of physical activity is associated with increased WHtR, body fat and BAI. Risk G allele is associated with increased fat accumulation in the studied cohort. Decreased level of physical activity enhanced the effect of UCP1 gene polymorphism rs1800592 on obesity-related traits in the studied cohort. Discussion. -3826A>G polymorphism of UCP1 (rs1800592) and decreased level of physical activity were associated with a higher risk of obesity in the studied cohort. The association between -3826A>G polymorphism of UCP1 (rs1800592) and obesity-related traits was modified by of physical activity. The combined effect of low level of physical activity and -3826A>G gene polymorphism of UCP1 (rs1800592) leads to a higher risk of obesity.

Keywords

central obesity; UCP1; gene-environment interactions; physical activity, anthropology, genetics of obesity

DOI: 10.32521/2074-8132.2020.4.090-098

Цит.: Parfenteva O.I. Association of 3826A >G UCP1 gene polymorphism and physical activity level with central obesity // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2020; 4/2020; с. 90-98