Moscow University
Anthropology
Bulletin

Relationship between FTO gene polymorphism with central obesity in ethnic Mongolians

Bondareva E.A. (1), Zadorozhnaya L.V. (1), Khomyakova I.A. (1), Permiakova E.Yu. (1), Godina E.Z. (1,2), Gundegmaa L.( 3), Otgon G. (4)

1) Lomonosov Moscow State University, Anuchin Research Institute and Museum of Anthropology, Mokhovaya st., 11, Moscow, 125009, Russia; 2) Russian state university of physical education, sport, youth and tourism (SCOLIPE), Sireneviy boulevard, 4, Moscow, 105122, Russia; 3) National Institute of Physical Culture of Mongolia, Ulaanbaatar city-13, Sukhbaatar district-43, Ulaanbaatar, Mongolia 4) Mongolian National University of Medical Sciences, Department of Physiology, School of Pharmacy and Bio-Medicine, 14210, S. Zorigh-3 St., Post-48/111, Ulaanbaatar, Mongolia

Bondareva Elvira A., PhD; ORCID ID: 0000-0003-3321-7575; Bondareva.E@gmail.com; Zadorozhnaya Liudmila V., PhD; ORCID ID: 0000-0002-3143-3226; mumla@rambler.ru; Khomiakova Irina A., PhD; ORCID ID: 0000-0002-2811-2034; Irina-khomyakova@yandex.ru; Permiakova Ekaterina Yu., PhD; ORCID ID: 0000-0002-6490-4004; ekaterinapermyakova@gmail.com; Godina Elena Z.,DSci, prof.; ORCID ID: 0000-0002-0692-420X; egodina@rambler.ru; Lkhagvasuren Gundegmaa, PhD; mongol_gunde@mail.ru; Otgon Galsanjav, DSci, prof.; ORCID ID: 0000-0002-6269-4533; otgon60@gmail.com.

Abstract

Materials and methods. 247 Mongolian males aged 18-24 years old were examined. The survey materials were collected from 2012 to 2018 in Ulaanbaator on the basis of the National Institute of Physical Culture of Mongolia and the National University of Medical Sciences. The biological material was collected using sterile urogenital probes (Type A Universal, Jingsu Suyun Medical Materials, China). For each subject participating in the study, the genotype was determined by the polymorphic systems of the T/A (rs9939609) polymorphism of the FTO gene was genotyped (Lytekh, Moscow). Results. The genotypes frequencies in subgroups with normal and high BMI were, respectively: FTO*TT 54.1% FTO*AT 33.3% and FTO*AA 12.6% FTO*TT 42.7% FTO*AT 41.5% and FTO*AA 15.8% (χ2 = 2.17, p = 0.33). The carriers of the two original alleles (TT * FTO) have thinner subscapular (U = 801.5 Z = -2.365 p = 0.016), biceps (U = 724.5 Z = -2.938 p = 0.003) and abdominal (U = 677.5 Z = -3.289 p = 0.0008) skinfolds compared with carriers of the heterozygous genotype. Pairwise comparisons in the subgroup with a normal BMI revealed statistically significant differences between carriers of TT and AA genotypes by chest (U = 138.5 Z = -2.37 p = 0.016) and hip (U = 130.0 Z = -2.54 p = 0.011) circumferences and the thickness of the skinfolds on triceps and biceps, as well as abdominal skinfold thickness (U = 144.5 Z = -2.46 p = 0.014). In the subgroup with high BMI, TT carriers significantly differ from AT only in the abdominal skinfold thickness (U = 356.5 Z = -2.996 p = 0.002). In both subgroups, carriers of AT and AA genotypes have no statistically significant morphological differences, which allow to judge the difference in fat accumulation, as well as specific patterns of its localization. Discussion. The results indicate that the presence of the A allele of the FTO gene is associated with an increased susceptibility to obesity in a group of young Mongolian males. A-allele carriers accumulate more fat with the same BMI, and mainly in the abdominal region, which indicates an increased risk of developing diseases associated with central obesity.

Keywords

anthropology; genetics; генетические маркеры; предикторы предрасположенности к ожирению; central obesity; BMI; Mongolians; young males

DOI: 10.32521/2074-8132.2019.3.055-066

Цит.: Bondareva E.A., Zadorozhnaya L.V., Khomyakova I.A., Permiakova E.Yu., Godina E.Z., Gundegmaa L.( 3), Otgon G. Relationship between FTO gene polymorphism with central obesity in ethnic Mongolians // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2019; 3/2019; с. 55-66

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