Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
Moscow Center of Advanced Sports Technologies, Sovietskoi Armii st, 6, Moscow, 129272, Russia
Parfenteva Olga Ivanovna, parfenteva.olga@gmail.com.
Introduction. Obesity results from complex gene-gene, gene-environment, and gene-lifestyle interactions. The common variants of the UCP genes show extreme population differentiation due to the adaptation to the environment. “Thrifty” alleles of the UCPs are associated with a higher risk of obesity, whereas ancestral alleles are likely to be protective. The aim of the study is to investigate the association between the “thermogenic” allele frequencies and environmental factors. Material and methods. Using allele frequencies data from 1000 Genomes Projects and climate data from NASA GISTEMP, the model was built to check if the variants of the UCP genes are involved in local adaptation to the environment. The following variants of the UCP genes were studied: UCP1 -3826 A>G (rs1800592), UCP2 Ala55Val (rs660339), UCP3 -55C>T (rs1800849). The generalized linear mixed model was used. Results. The “thermogenic” variants of the UCP genes can be potentially involved in local adaptation to the environment. Discussion. The “thermogenic” variants of the UCP genes are protective against obesity and metabolic disorders. The local adaptation may have contributed to the genetic differences in populations with various ethnic backgrounds and a higher risk of obesity in some populations compared to another.
uncoupling proteins; UCP; local adaptation; genetic population structure; environment
DOI: 10.32521/2074-8132.2019.2.126-133
Цит.: Parfenteva O.I. Latitude variation of the uncoupling proteins gene frequencies for obesity in human populations // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2019; 2/2019; с. 126-133
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