Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
1) Lomonosov Moscow State University, Research Institute and Museum of Anthropology, Mokhovaya St., 11, Moscow, 125009, Russia; 2) Russian State University of Physical Education, Sport, Youth and Tourism (SCOLIPE), Sireneviy boulevard, 4, Moscow, 105122, Russia; 3) Gorno Altaisk State University, Lenkina St., 1, Gorno-Altaisk, 649000, Russia; 4) Mongolian National University of Medical Sciences, Department of Physiology, School of Pharmacy and Bio-Medicine, 14210, S. Zorigh-3 St., Post-48/111, Ulaanbaatar, Mongolia
Bondareva Elvira Aleksandrovna, PhD; ORCID ID 0000-0003-3321-7575; Bondareva.E@gmail.com; Makhalin Adu Vasilievich, assistant professor, PhD,fiziologi@mail.ru; Popova Elena Viktorovna, assistant professor, PhD,ms.biolog@mail.ru; Otgon Galsanjav, prof. ScDr., otgon60@gmail.com; Zadorozhnaya Liudmila Viktorovna, PhD; ORCID ID 0000-0002-3143-3226; mumla@rambler.ru; Khomiakova Irina Anatolievna, assistant professor, PhD; ORCID ID 0000-0002-2811-2034; irina-khomyakova@yandex.ru; Godina Elena Zinovievna, professor, PhD, D. Sc.; ORCID ID 0000-0002-0692-420X; egodina11@gmail.com.
The aim of this paper is the study of the distribution of alleles and genotype frequencies of T/A – polymorphism of FTO gene in four different ethnic groups (Kalmyk, Russian and Altaians) in Russia and Mongols in Ulaanbaatar. Materials and methods. 913 volunteers took part in the study -189 Altaians (70 females и 119 males), 83 Kalmyks (33 females и 50 males), 171 Mongols (130 females и 141 males) in Ulaanbaatar and 479 Russians (246 females и 233 males). Buccal smears were collected, and genomic DNA was isolated. FTO (T/A, rs9939609) genotyping was performed by «Lytech» (Moscow). Results. Significant differences of the genotype distributions of FTO gene between studied monoethnic groups were found (χ 2 = 164,3, df = 6, p < 0,0001). All studied groups demonstrate relatively similar frequencies of FTO*AA (36,5% Altaians, 24,1% Kalmyks, 33,2% Russians) excluding Mongols 10,5%, but FTO*TT genotype frequencies are different - 3,7% Altaians, 16,4% Russians, 50,6% Kalmyks and 49,7% Mongols. There were no significant differences in genotype distributions between female and male subsamples in all studied ethnic groups. Among Russians living in three different cities (Moscow, Arkhangelsk, and Saransk) significant differences in FTO genotype distributions were found (χ 2 = 19,5, p = 0,0006). Discussion. We have found that studied populations demonstrate different genetic predisposition to obesity. Also, among the same ethnic group, FTO genotype differences are not equal and depend on the region of living. To predict population-based risks of obesity both ethnicity and region of living should be taken into consideration.
FTO; obesity; polymorphism; ethnic groups; Altaians; Kalmyks; Mongols; Russians
DOI: 10.32521/2074-8132.2018.4.043-048
Цит.: Bondareva E.A., Makhalin A.V., Popova E.V., Otgon G., Zadorozhnaya L.V., Khomyakova I.A., Godina E.Z. Obesity predisposition associated with FTO gene polymorphism among different ethnic groups of Russia and Mongolia // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2018; 4/2018; с. 43-48
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