Moscow University
Anthropology
Bulletin

Investigation of sex- and age-related differences of human choroid plexus and ventricles organization

Yuneman O.A. (1), Saveliev S.V. (1), Rud S.D. (2)

1) Research Institut of Human Morphology of Russian Academy of Medical Science, Moscow; 2) Kirov Military Medical Academy, St. Petersburg

Yuneman O.A., e-mail: ojunemann@yandex.ru; Saveliev S.V.; Rud S.D.

Abstract

In spite of numerous data on anatomy, physiology, embriogenesis, pathologies of plexus choroid, some question are left opened. Sexual dimorphism’s presence in frequency of occurrence of an intracranial hypertensia, various forms of a hydrocephaly and migraines have been established. These diseases are related with disorders of dinamic of liquor which, perhaps, in turn depends on such factors, as volume ratious of a brain, ventricles and vascular plesus, and also from a histologic structure of plexus: organisation of epithelial cells, presence of fibromatosis, quantities of concrements and age changes. The purpose of the present research was the research of morphological and functional features of sex- and age-related differences in the organizations of choroid plexus and ventricles of the human brain and reception of an indirect estimation of cerebrospinal fluid flow speed. The research was carried out on a section material (69 persons) and materials of a magnitno-resonant and computed tomography (92 persons). Results of research have been processed by means of statistical software package STATISTICA 6.0. For revealing of sexual differences between volumes of a brain, lateral ventricles and choroid plexus Student’s t-test has been used. Then correlations has been calculated. Correlation coefficient showing relationship of volumes of ventricles and plexus with the age has been also calculated. Histologic research was made on choroid plexus of lateral ventricles of the male and female brains at the age 27 between 96 years (69 autopsies). Paraffin sections of choroid plexus were colored on a Mallori and Van Gison methods and by gematoksilin-eozin. Dependence of following parameters on a sex and age has been tracked: thickening of walls of vessels, the size and way of the organization of villi’s capillaries, organisation of filtering and not filtering epithelial zones, quantity of concrements, presence of a fibromatosis, disease and a cause of death. Contingency tables have been prepared and Pirson and Kramer coefficients are calculated. The correlation coefficient between volumes of lateral ventricles and age is -0,36 for male and -0,38 for female. The correlation coefficient between volumes of vascular plexus and age both for male and female groups is doubtful. The correlation coefficient between volumes of the brain and ventricles is 0,48 for male and 0,56 for female. It allows to speak about relationship of volume of ventricles with brain volume only at tendency level. The histological analysis has revealed absence of accurate relationship in a structure of vascular plexus depending on a sex and age. In the present research tendencies to relationship between volumes of the brain and ventricles are revealed. And absence of distinct relationship between volumes of a brain and vascular plexus of human brain are revealed. Absence of significant sex- and age-related changes in the organization of lateral ventricles and choroid plexus is shown. Histilogical investigation detected absence of distinct sex- and age-related differences in human choroid plexus and ventricles structure. This results confirm that speed of a channel of a cerebrospinal fluid is the value characterized by strong variability.

Keywords

choroid plexus of human brain, sex- and age-related differences, tomographic imaging, histological analysis

Цит.: Yuneman O.A., Saveliev S.V., Rud S.D. Investigation of sex- and age-related differences of human choroid plexus and ventricles organization // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2011; 4/2011; с. 93-98

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