Moscow University
Anthropology
Bulletin
Anthropology
Bulletin
Graduate School of Engineering, Chiba University, Chiba, Japan
Yoshida Hisao, e-mail: yoshida_hisao@chiba-u.jp.
A decrease in central venous pressure caused by orthostatic stress reduces the cerebral blood flow. Lower-body negative pressure is used as a perturbation to the cardiovascular system and has been applied to simulate the gravitational stress of orthostatic blood shift in humans. However, little is known about how dynamic changes in the cerebral blood flow affect brain activity. Using sinusoidal lower-body negative pressure (SLBNP) as a postural blood shift simulation and event-related potentials (ERPs) extracted from electroencephalograms (EEGs) of subjects engaged in an oddball task, we assessed whether mild blood pressure fluctuations disturbed brain activity. The middle cerebral arterial blood flow velocity (MCAv) and cerebral blood oxygenation (OxyHb) were measured in 11 healthy male adults. Two different periodical changes (18- and 90-sec of 0 to −40 mmHg) of SLBNP were provided. We observed that the fluctuations of MCAv and OxyHb coincided with the SLBNP. We found that the N100 amplitude evoked by standard stimuli at 18-sec was significantly decreased compared to the 90-sec SLBNP and to the one without-SLBNP condition, but there was no significant effect of SLBNP on the P300 amplitude. These results indicate that SLBNP affected the cerebral blood flow, whose fluctuations affected brain activity. Our findings suggest that there is a relationship between mild fluctuations of cerebral blood flow and brain activity.
cerebral blood flow, event-related potentials, lower-body negative pressure
Цит.: Yoshida Hisao, Ootaka Masaki, Ishibashi Keita, Iwanaga Koichi EFFECT OF SINUSOIDAL LOWER-BODY NEGATIVE PRESSURE ON CEREBRAL BLOOD FLOW AND EVENT-RELATED POTENSIALS // Moscow University Anthropology Bulletin (Vestnik Moskovskogo Universiteta. Seria XXIII. Antropologia), 2014; 3/2014; с. 136-136
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